A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig.

ABSTRACT: Genetic variations through their effects on gene expression and protein function underlie disease susceptibility in farm animal species. The variations are in the form of single nucleotide polymorphisms, deletions/insertions of nucleotides or whole genes, gene or whole chromosomal rearrangements, gene duplications, and copy number polymorphisms or variants. They exert varying degrees of effects on gene action, such as substitution of an amino acid for another, shift in reading frame and premature termination of translation, and complete deletion of entire exon(s) or gene(s) in diseased individuals. These factors influence gene function by affecting mRNA splicing pattern or by altering/eliminating protein function. Elucidating the genetic bases of diseases under the control of many genes is

SUBMITTER: Ibeagha-Awemu EM 

PROVIDER: S-EPMC2323435 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature