Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study.

ABSTRACT: A critical property of some neurons is burst firing, which in the hippocampus plays a primary role in reliable transmission of electrical signals. However, bursting may also contribute to synchronization of electrical activity in networks of neurons, a hallmark of epilepsy. Understanding the ionic mechanisms of bursting in a single neuron, and how mutations associated with epilepsy modify these mechanisms, is an important building block for understanding the emergent network behaviors. We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation. The single compartment model incorporates accurate representations of sodium (Na(+)) channels (Na(V

SUBMITTER: Xu J 

PROVIDER: S-EPMC2323611 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature