OptCircuit: an optimization based method for computational design of genetic circuits.

ABSTRACT:

Background

Recent years has witnessed an increasing number of studies on constructing simple synthetic genetic circuits that exhibit desired properties such as oscillatory behavior, inducer specific activation/repression, etc. It has been widely acknowledged that that task of building circuits to meet multiple inducer-specific requirements is a challenging one. This is because of the incomplete description of component interactions compounded by the fact that the number of ways in which one can chose and interconnect components, increases exponentially with the number of components.

Results

In this paper we introduce OptCircuit, an optimization based framework that automatically identifies the circuit components from a list and connectivity that brings about the desired func

SUBMITTER: Dasika MS 

PROVIDER: S-EPMC2324073 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature