Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population.

ABSTRACT:

Background

Chromosome 15q14-22.1 has been linked to type 2 diabetes (T2D) and its related traits in Japanese and other populations. The presence of T2D disease susceptibility variant(s) was assessed in the 21.8 Mb region between D15S118 and D15S117 in a Japanese population using a region-wide case-control association test.

Methods

A two-stage association test was performed using Japanese subjects: The discovery panel (Stage 1) used 372 cases and 360 controls, while an independent replication panel (Stage 2) used 532 cases and 530 controls. A total of 1,317 evenly-spaced, common SNP markers with minor allele frequencies > 0.10 were typed for each stage. Captured genetic variation was examined in HapMap JPT SNPs, and a haplotype-based association test was performed.

Results

SUBMITTER: Yamaguchi Y 

PROVIDER: S-EPMC2324080 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature