How reliably can we predict the reliability of protein structure predictions?

ABSTRACT:

Background

Comparative methods have been the standard techniques for in silico protein structure prediction. The prediction is based on a multiple alignment that contains both reference sequences with known structures and the sequence whose unknown structure is predicted. Intensive research has been made to improve the quality of multiple alignments, since misaligned parts of the multiple alignment yield misleading predictions. However, sometimes all methods fail to predict the correct alignment, because the evolutionary signal is too weak to find the homologous parts due to the large number of mutations that separate the sequences.

Results

Stochastic sequence alignment methods define a posterior distribution of possible multiple alignments. They can highlight the most likel

SUBMITTER: Miklos I 

PROVIDER: S-EPMC2324098 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature