Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q.

ABSTRACT:

Background

Colorectal cancer is one of the most common causes of cancer-related mortality. The disease is clinically and genetically heterogeneous though a strong hereditary component has been identified. However, only a small proportion of the inherited susceptibility can be ascribed to dominant syndromes, such as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) or Familial Adenomatous Polyposis (FAP). In an attempt to identify novel colorectal cancer predisposing genes, we have performed a genome-wide linkage analysis in 30 Swedish non-FAP/non-HNPCC families with a strong family history of colorectal cancer.

Methods

Statistical analysis was performed using multipoint parametric and nonparametric linkage.

Results

Parametric analysis under the assumption of locus ho

SUBMITTER: Picelli S 

PROVIDER: S-EPMC2324103 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature