Immunohistochemical localization of collagen type XI alpha1 and alpha2 chains in human colon tissue.

ABSTRACT: In previous studies, collagen XI mRNA has been detected in colon cancer, but its location in human colon tissue has not been determined. The heterotrimeric collagen XI consists of three alpha chains. While it is known that collagen XI plays a regulatory role in collagen fibril formation, its function in the colon is unknown. The characterization of normal human colon tissue will allow a better understanding of the variance of collagen XI in abnormal tissues. Grossly normal and malignant human colon tissue was obtained from pathology archives. Immunohistochemical staining with a 58K Golgi marker and alpha1(XI) and alpha2(XI) antisera was used to specifically locate their presence in normal colon tissue. A comparative bright field microscopic analysis showed the presence of collagen XI in hu

SUBMITTER: Bowen KB 

PROVIDER: S-EPMC2324180 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature