R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.

ABSTRACT:

Background

Up to now, two loci have been involved in XX sex-reversal in mammals following loss-of-function mutations, PIS (Polled Intersex Syndrome) in goats and R-spondin1 (RSPO1) in humans. Here, we analyze the possible interaction between these two factors during goat gonad development. Furthermore, since functional redundancy between different R-spondins may influence gonad development, we also studied the expression patterns of RSPO2, 3 and 4.

Results

Similarly to the mouse, RSPO1 shows a sex-dimorphic expression pattern during goat gonad development with higher levels in the ovaries. Interestingly, the PIS mutation does not seem to influence its level of expression. Moreover, using an RSPO1 specific antibody, the RSPO1 protein was localized in the cortical area of earl

SUBMITTER: Kocer A 

PROVIDER: S-EPMC2329615 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature