The human ABC transporter pseudogene family: Evidence for transcription and gene-pseudogene interference.

ABSTRACT:

Background

Pseudogenes are an integral component of the human genome. Little attention, however, has so far been paid to the phenomenon that some pseudogenes are transcriptionally active. Recently, we demonstrated that the human ortholog of the rodent testis-specific ATP-binding cassette (ABC) transporter Abca17 is a ubiquitously transcribed pseudogene (ABCA17P). The aim of the present study was to establish a complete inventory of all ABC transporter pseudogenes in the human genome and to identify transcriptionally active ABC transporter pseudogenes. Moreover, we tested the hypothesis that a regulatory interdependency exists between ABC transporter pseudogenes and their parental protein coding equivalents.

Results

Systematic bioinformatic analysis revealed the existence of

SUBMITTER: Piehler AP 

PROVIDER: S-EPMC2329642 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature