Impact of Transcription Units rearrangement on the evolution of the regulatory network of gamma-proteobacteria.

ABSTRACT:

Background

In the past years, several studies begun to unravel the structure, dynamical properties, and evolution of transcriptional regulatory networks. However, even those comparative studies that focus on a group of closely related organisms are limited by the rather scarce knowledge on regulatory interactions outside a few model organisms, such as E. coli among the prokaryotes.

Results

In this paper we used the information annotated in Tractor_DB (a database of regulatory networks in gamma-proteobacteria) to calculate a normalized Site Orthology Score (SOS) that quantifies the conservation of a regulatory link across thirty genomes of this subclass. Then we used this SOS to assess how regulatory connections have evolved in this group, and how the variation of basic regul

SUBMITTER: Gonzalez Perez AD 

PROVIDER: S-EPMC2329645 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature