Transcriptomics and adaptive genomics of the asymptomatic bacteriuria Escherichia coli strain 83972.

ABSTRACT: Escherichia coli strains are the major cause of urinary tract infections in humans. Such strains can be divided into virulent, UPEC strains causing symptomatic infections, and asymptomatic, commensal-like strains causing asymptomatic bacteriuria, ABU. The best-characterized ABU strain is strain 83972. Global gene expression profiling of strain 83972 has been carried out under seven different sets of environmental conditions ranging from laboratory minimal medium to human bladders. The data reveal highly specific gene expression responses to different conditions. A number of potential fitness factors for the human urinary tract could be identified. Also, presence/ absence data of the gene expression was used as an adaptive genomics tool to model the gene pool of 83972 using primarily UPEC s

SUBMITTER: Hancock V 

PROVIDER: S-EPMC2329726 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature