Transcriptional regulation of NAD metabolism in bacteria: NrtR family of Nudix-related regulators.

ABSTRACT: A novel family of transcription factors responsible for regulation of various aspects of NAD synthesis in a broad range of bacteria was identified by comparative genomics approach. Regulators of this family (here termed NrtR for Nudix-related transcriptional regulators), currently annotated as ADP-ribose pyrophosphatases from the Nudix family, are composed of an N-terminal Nudix-like effector domain and a C-terminal DNA-binding HTH-like domain. NrtR regulons were reconstructed in diverse bacterial genomes by identification and comparative analysis of NrtR-binding sites upstream of genes involved in NAD biosynthetic pathways. The candidate NrtR-binding DNA motifs showed significant variability between microbial lineages, although the common consensus sequence could be traced for most of the

SUBMITTER: Rodionov DA 

PROVIDER: S-EPMC2330246 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature