Ischemia of the lung causes extensive long-term pulmonary injury: an experimental study.

ABSTRACT:

Background

Lung ischemia-reperfusion injury (LIRI) is suggested to be a major risk factor for development of primary acute graft failure (PAGF) following lung transplantation, although other factors have been found to interplay with LIRI. The question whether LIRI exclusively results in PAGF seems difficult to answer, which is partly due to the lack of a long-term experimental LIRI model, in which PAGF changes can be studied. In addition, the long-term effects of LIRI are unclear and a detailed description of the immunological changes over time after LIRI is missing. Therefore our purpose was to establish a long-term experimental model of LIRI, and to study the impact of LIRI on the development of PAGF, using a broad spectrum of LIRI parameters including leukocyte kinetics.

Meth

SUBMITTER: van der Kaaij NP 

PROVIDER: S-EPMC2335107 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature