Segment Coupling to a Highly Hindered N-Terminal, Alamethicin-Related alpha-Aminoisobutyric Acid (Aib) Residue.

ABSTRACT: A model [6 + 5] segment coupling process involving a C-terminal valine hexapeptide acid and a resin-attached pentapeptide amide which N-terminated in a hindered Aib unit was examined using a variety of HOAt-derived coupling reagents. Best results were observed with HAPyU in DCM solvent in which loss of configuration amounted to 5.8%.

SUBMITTER: Carpino LA 

PROVIDER: S-EPMC2344146 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature