Synthesis of hindered biphenyls by sequential non-transition metal-catalyzed reaction/palladium-catalyzed cross-couplings.

ABSTRACT: The sequential reaction of 1,2-dihalobenzenes with aryl lithiums followed by palladium-catalyzed cross-coupling reactions with Grignard reagents and arylboronic acids is described. This sequential reaction provides a convenient and expeditious access to tri-ortho substituted biaryl derivatives.

SUBMITTER: He P 

PROVIDER: S-EPMC2350223 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature