Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites.

ABSTRACT: Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker encodes a homologue of the moth Gram-negative bacteria-binding protein (GNBP), and another corresponds to a serine protease-like molecule. Additional previously described markers that respond to immune challenge encode the antimicrobial peptide defensin, a putative galactose lectin, and a putative serine protease. Specificity of the immune responses was indicated by differing temporal patterns of induction of specific markers in bacteria-challenged larvae and adults, and by variations in the effectiveness of different microorganisms and their components for marker induction in an immune-responsive

SUBMITTER: Dimopoulos G 

PROVIDER: S-EPMC23521 | biostudies-literature | 1997 Oct

REPOSITORIES: biostudies-literature