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HSK4, a member of a novel subfamily of calcium-activated potassium channels.


ABSTRACT: The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells. In physiological saline hSK4 generates a conductance of approximately 12 pS, a value in close agreement with that of other cloned SK channels. Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function. hSK4 appears unique, however, in its very high affinity for Ca2+ (EC50 of 95 nM) and its predominant expression in nonexcitable tissues of adult animals. Together with the relatively low homology of hSK4 to other SK channel polypeptides (approximately 40% identical), these data suggest that hSK4 belongs to a novel subfamily of SK channels.

SUBMITTER: Joiner WJ 

PROVIDER: S-EPMC23566 | biostudies-literature | 1997 Sep

REPOSITORIES: biostudies-literature

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hSK4, a member of a novel subfamily of calcium-activated potassium channels.

Joiner W J WJ   Wang L Y LY   Tang M D MD   Kaczmarek L K LK  

Proceedings of the National Academy of Sciences of the United States of America 19970901 20


The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells. In physiological saline hSK4 generates a conductance of approximately 12 pS, a value in close agreement with that of other cloned SK channels. Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function. hSK4 appears unique, howe  ...[more]

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