Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells.

ABSTRACT:

Background

Neuronal tissue has limited potential to self-renew or repair after neurological diseases. Cellular therapies using stem cells are promising approaches for the treatment of neurological diseases. However, the clinical use of embryonic stem cells or foetal tissues is limited by ethical considerations and other scientific problems. Thus, bone marrow mesenchymal stomal cells (BM-MSC) could represent an alternative source of stem cells for cell replacement therapies. Indeed, many studies have demonstrated that MSC can give rise to neuronal cells as well as many tissue-specific cell phenotypes.

Methods

BM-MSC were differentiated in neuron-like cells under specific induction (NPBM + cAMP + IBMX + NGF + Insulin). By day ten, differentiated cells presented an expression p

SUBMITTER: Tondreau T 

PROVIDER: S-EPMC2358905 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature