Persistent cell motion in the absence of external signals: a search strategy for eukaryotic cells.

ABSTRACT:

Background

Eukaryotic cells are large enough to detect signals and then orient to them by differentiating the signal strength across the length and breadth of the cell. Amoebae, fibroblasts, neutrophils and growth cones all behave in this way. Little is known however about cell motion and searching behavior in the absence of a signal. Is individual cell motion best characterized as a random walk? Do individual cells have a search strategy when they are beyond the range of the signal they would otherwise move toward? Here we ask if single, isolated, Dictyostelium and Polysphondylium amoebae bias their motion in the absence of external cues.

Methodology

We placed single well-isolated Dictyostelium and Polysphondylium cells on a nutrient-free agar surface and followed them at 1

SUBMITTER: Li L 

PROVIDER: S-EPMC2358978 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature