Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa.

ABSTRACT: The heterogeneous nuclear ribonucleoprotein K (hnRNP K) protein is an RNA-binding protein involved in many processes that compose gene expression. K protein is upregulated in the malignant processes and has been shown to modulate the expression of genes involved in mitogenic responses and tumorigenesis. To explore the possibility that there are alternative isoforms of K protein expressed in colon cancer, we amplified and sequenced K protein mRNA that was isolated from colorectal cancers as well as from normal tissues surrounding the tumours. Sequencing revealed a single G-to-A base substitution at position 274 that was found in tumours and surrounding mucosa, but not in individuals that had no colorectal tumour. This substitution most likely reflects an RNA editing event because it was not

SUBMITTER: Klimek-Tomczak K 

PROVIDER: S-EPMC2361188 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature