Towards third generation matrix metalloproteinase inhibitors for cancer therapy.
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ABSTRACT:
SUBMITTER: Overall CM
PROVIDER: S-EPMC2361222 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Publications
Towards third generation matrix metalloproteinase inhibitors for cancer therapy.
British journal of cancer 20060401 7
The failure of matrix metalloproteinase (MMP) inhibitor drug clinical trials in cancer was partly due to the inadvertent inhibition of MMP antitargets that counterbalanced the benefits of MMP target inhibition. We explore how MMP inhibitor drugs might be developed to achieve potent selectivity for validated MMP targets yet therapeutically spare MMP antitargets that are critical in host protection. ...[more]
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