Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer.

ABSTRACT: Lung cancer is the leading cause of cancer-related mortality in the world, with small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) comprising the two major cell types. Although these cell types can be distinguished readily at the histological level, knowledge of their underlying molecular differences is very limited. In this study, we compared 14 SCLC cell lines against 27 NSCLC cell lines using an integrated array comparative genomic hybridisation and gene expression profiling approach to identify subtype-specific disruptions. Using stringent criteria, we have identified 159 of the genes that are responsible for the different biology of these cell types. Sorting of these genes by their biological functions revealed the differential disruption of key components involved i

SUBMITTER: Coe BP 

PROVIDER: S-EPMC2361340 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature