Modulation of lymphocyte proliferation by antioxidants in chronic beryllium disease.

ABSTRACT:

Rationale

Occupational exposure to beryllium (Be) can result in chronic granulomatous inflammation characterized by the presence of Be-specific CD4+ T cells. Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders.

Objectives

We hypothesized that Be-induced oxidative stress modulates the proliferation of Be-specific CD4+ T cells.

Methods

Thirty-three subjects with chronic beryllium disease (CBD), 15 subjects with beryllium sensitization, and 28 healthy normal control subjects were consecutively enrolled from the Occupational and Environmental Health Clinic of the National Jewish Medical and Research Center.

Measurements and main results

All studies were performed with Ficoll-Hypaque-isolated peripheral blood mononuc

SUBMITTER: Dobis DR 

PROVIDER: S-EPMC2361422 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature