Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.

ABSTRACT:

Rationale

Nuclear factor (NF)-kappaB is a prominent proinflammatory transcription factor that plays a critical role in allergic airway disease. Previous studies demonstrated that inhibition of NF-kappaB in airway epithelium causes attenuation of allergic inflammation.

Objectives

We sought to determine if selective activation of NF-kappaB within the airway epithelium in the absence of other agonists is sufficient to cause allergic airway disease.

Methods

A transgenic mouse expressing a doxycycline (Dox)-inducible, constitutively active (CA) version of inhibitor of kappaB (IkappaB) kinase-beta (IKKbeta) under transcriptional control of the rat CC10 promoter, was generated.

Measurements and main results

After administration of Dox, expression of the CA-IKKbeta tra

SUBMITTER: Pantano C 

PROVIDER: S-EPMC2361423 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature