Reducing the false positive rate in the non-parametric analysis of molecular coevolution.

ABSTRACT:

Background

The strength of selective constraints operating on amino acid sites of proteins has a multifactorial nature. In fact, amino acid sites within proteins coevolve due to their functional and/or structural relationships. Different methods have been developed that attempt to account for the evolutionary dependencies between amino acid sites. Researchers have invested a significant effort to increase the sensitivity of such methods. However, the difficulty in disentangling functional co-dependencies from historical covariation has fuelled the scepticism over their power to detect biologically meaningful results. In addition, the biological parameters connecting linear sequence evolution to structure evolution remain elusive. For these reasons, most of the evolutionary studies

SUBMITTER: Codoner FM 

PROVIDER: S-EPMC2362121 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature