Hierarchical effector protein transport by the Salmonella Typhimurium SPI-1 type III secretion system.

ABSTRACT:

Background

Type III secretion systems (TTSS) are employed by numerous pathogenic and symbiotic bacteria to inject a cocktail of different "effector proteins" into host cells. These effectors subvert host cell signaling to establish symbiosis or disease.

Methodology/principal findings

We have studied the injection of SipA and SptP, two effector proteins of the invasion-associated Salmonella type III secretion system (TTSS-1). SipA and SptP trigger different host cell responses. SipA contributes to triggering actin rearrangements and invasion while SptP reverses the actin rearrangements after the invasion has been completed. Nevertheless, SipA and SptP were both pre-formed and stored in the bacterial cytosol before host cell encounter. By time lapse microscopy, we observed tha

SUBMITTER: Winnen B 

PROVIDER: S-EPMC2364654 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature