A transcriptional enhancer from the coding region of ADAMTS5.

ABSTRACT:

Background

The revelation that the human genome encodes only approximately 25,000 genes and thus cannot account for phenotypic complexity has been one of the biggest surprises in the post-genomic era. However, accumulating evidence suggests that transcriptional regulation may be in large part responsible for this observed mammalian complexity. Consequently, there has been a strong drive to locate cis-regulatory regions in mammalian genomes in order to understand the unifying principles governing these regions, including their genomic distribution. Although a number of systematic approaches have been developed, these all discount coding sequence.

Methodology/principal findings

Using the computational tool PRI (Pattern-defined Regulatory Islands), which does not mask coding se

SUBMITTER: Barthel KK 

PROVIDER: S-EPMC2364661 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature