A scoring matrix approach to detecting miRNA target sites.

ABSTRACT:

Background

Experimental identification of microRNA (miRNA) targets is a difficult and time consuming process. As a consequence several computational prediction methods have been devised in order to predict targets for follow up experimental validation. Current computational target prediction methods use only the miRNA sequence as input. With an increasing number of experimentally validated targets becoming available, utilising this additional information in the search for further targets may help to improve the specificity of computational methods for target site prediction.

Results

We introduce a generic target prediction method, the Stacking Binding Matrix (SBM) that uses both information about the miRNA as well as experimentally validated target sequences in the search fo

SUBMITTER: Moxon S 

PROVIDER: S-EPMC2365947 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature