Systematic determination of differential gene expression in the primate corpus luteum during the luteal phase of the menstrual cycle.

ABSTRACT: The molecular and cellular processes required for development, function, and regression of the primate corpus luteum (CL) are poorly defined. We hypothesized that there are dynamic changes in gene expression occurring during the CL life span, which represent proteins and pathways critical to its regulation. Therefore, a genomic approach was utilized to systematically identify differentially expressed genes in the rhesus macaque CL during the luteal phase of natural menstrual cycles. CL were collected between d 3-5 (early stage), d 7-8 (mid), d 10-12 (mid-late), d 14-16 (late), or d 18-19 (very-late) after the midcycle LH surge. From the early through very-late stages, 3234 transcripts were differentially expressed, with 879 occurring from the early through late stages that encompass the pr

SUBMITTER: Bogan RL 

PROVIDER: S-EPMC2366192 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature