Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor.

ABSTRACT: Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and physiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Although consistency between mRNA and proteins is often implicitly assumed in many studies, examples of divergent trends are frequently observed. Here, we present a comparative transcriptome and proteome analysis of growth and stationary phase adaptation in Streptomyces coelicolor, taking the time-dynamics of process into consideration. These processes are of immense interest in microbiology as they pertain to the physiological transformations eliciting biosynthesis of many naturally occurring therapeutic agents. A shotgun proteomics approach based

SUBMITTER: Jayapal KP 

PROVIDER: S-EPMC2367054 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature