Ontology highlight
ABSTRACT:
SUBMITTER: Nemeth A
PROVIDER: S-EPMC2367401 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20080320 8
Ribosomal RNA synthesis is the eukaryotic cell's main transcriptional activity, but little is known about the chromatin domain organization and epigenetics of actively transcribed rRNA genes. Here, we show epigenetic and spatial organization of mouse rRNA genes at the molecular level. TTF-I-binding sites subdivide the rRNA transcription unit into functional chromatin domains and sharply delimit transcription factor occupancy. H2A.Z-containing nucleosomes occupy the spacer promoter next to a newl ...[more]