Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

ABSTRACT:

Background

Rheumatoid arthritis (RA, MIM 180300) is a common and complex inflammatory disorder. The North American Rheumatoid Arthritis Consortium (NARAC) data, as part of the Genetic Analysis Workshop 15 data, consists of both genome scan and candidate gene studies on RA patients.

Results

We applied the backward genotype-trait association (BGTA) algorithm to capture marginal and gene x gene interaction effects of multiple susceptibility loci on RA disease status. A two-stage screening approach was used for the genome scan, whereas a comprehensive study of all possible subsets was conducted for the candidate genes. For the genome scan, we constructed an association network among 39 genetic loci that demonstrated strong signals, 19 of which have been reported in the RA litera

SUBMITTER: Ding Y 

PROVIDER: S-EPMC2367461 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature