Empirically derived subgroups in rheumatoid arthritis: association with single-nucleotide polymorphisms on chromosome 6.

ABSTRACT: Rheumatoid arthritis (RA) is a disorder with important public health implications. It is possible that there are clinically distinctive subtypes of the disorder with different genetic etiologies. We used the data provided to the participants in the Genetic Analysis Workshop 15 to evaluate and describe clinically based subgroups and their genetic associations with single-nucleotide polymorphisms (SNPs) on chromosome 6, which harbors the HLA region. Detailed two- and three-SNP haplotype analyses were conducted in the HLA region. We used demographic, clinical self-report, and biomarker data from the entire sample (n = 8477) to identify and characterize the subgroups. We did not use the RA diagnosis itself in the identification of the subgroups. Nuclear families (715 families, 1998 individuals

SUBMITTER: Wilcox MA 

PROVIDER: S-EPMC2367493 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature