No evidence for multiple loci affecting rheumatoid arthritis risk on chromosome 6p21.

ABSTRACT: The influence of certain alleles of the HLA-DRB1 locus on risk for rheumatoid arthritis has been well established through linkage and association studies. In addition, other loci in the HLA region on 6p21 may also affect an individual's risk profile. Here, we used a method to detect excess identity-by-descent sharing between affected sib pairs conditional on the observed genotypes at the hypothesized causal locus to test for the presence of additional arthritis risk loci in the linked region. We used affected sib pairs from two different studies. Because the test depends heavily on specifying accurate allele frequency estimates at the proposed causal locus, we used HLA-DRB1 allele frequency estimates from a large, population-based sample. We also discuss an alternate form of the test in wh

SUBMITTER: Sherva R 

PROVIDER: S-EPMC2367585 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature