Co-regulation and multilocus determinants of gene expression in humans.

ABSTRACT:

Background

The regulation of gene expression is an emerging area of investigation. Increased knowledge can deepen our understanding of the genetic contributions to variations in complex traits. The purpose of this study is to explore the feasibility of detecting regulatory elements of gene expression with multivariate analyses.

Methods

Peripheral blood lymphocyte expression levels of 30 genes on chromosome 5 and a single gene, DEAD, on chromosome 22 were analyzed in single-point variance-component linkage analyses in multiplex families to identify putative regulatory regions. To explore the possibility of regulatory regions having individual relationships with the expression levels of a single gene, we utilized stepwise regression. To explore the possibility of pleiotropy of

SUBMITTER: Kerner B 

PROVIDER: S-EPMC2367586 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature