Mapping proteins to disease terminologies: from UniProt to MeSH.

ABSTRACT:

Background

Although the UniProt KnowledgeBase is not a medical-oriented database, it contains information on more than 2,000 human proteins involved in pathologies. However, these annotations are not standardized, which impairs the interoperability between biological and clinical resources. In order to make these data easily accessible to clinical researchers, we have developed a procedure to link diseases described in the UniProtKB/Swiss-Prot entries to the MeSH disease terminology.

Results

We mapped disease names extracted either from the UniProtKB/Swiss-Prot entry comment lines or from the corresponding OMIM entry to the MeSH. Different methods were assessed on a benchmark set of 200 disease names manually mapped to MeSH terms. The performance of the retained procedure in

SUBMITTER: Mottaz A 

PROVIDER: S-EPMC2367626 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature