Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC2373348 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20080424 18
Indoleamine 2,3 dioxygenase (IDO) has emerged as an important mediator of immune tolerance via inhibition of Th1 responses. However, the role of IDO in antigen-induced tolerance or allergic inflammation in the airways that is regulated by Th2 responses has not been elucidated. By using IDO(-/-) mice, we found no impairment of airway tolerance, but, surprisingly, absence of IDO provided significant relief from establishment of allergic airways disease, as evident from attenuated Th2 cytokine prod ...[more]