A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.

ABSTRACT: Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic, transcriptional and translational mechanisms. In contrast, very little is known about the molecular and cellular mechanisms underlying later stages of memory, including remote memory (i.e. 7-day memory). To identify genes required for remote memory, we screened randomly selected mouse strains harboring known mutations. In our primary reverse genetic screen, we identified 4 putative remote memory mutant strains out of a total of 54 lines analyzed. Additionally, we found 11 other mutant strains with other abnormal profiles. Secondary screens confirmed that mutations of integrin beta2 (Itgbeta2) and steryl-O-acyl transferase 1 (Soat1) specifically disrupted remote memory. Thi

SUBMITTER: Matynia A 

PROVIDER: S-EPMC2373872 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature