Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna.

ABSTRACT:

Background

Ibuprofen and other nonsteroidal anti-inflammatory drugs have been designed to interrupt eicosanoid metabolism in mammals, but little is known of how they affect nontarget organisms. Here we report a systems biology study that simultaneously describes the transcriptomic and phenotypic stress responses of the model crustacean Daphnia magna after exposure to ibuprofen.

Results

Our findings reveal intriguing similarities in the mode of action of ibuprofen between vertebrates and invertebrates, and they suggest that ibuprofen has a targeted impact on reproduction at the molecular, organismal, and population level in daphnids. Microarray expression and temporal real-time quantitative PCR profiles of key genes suggest early ibuprofen interruption of crustacean eicosanoi

SUBMITTER: Heckmann LH 

PROVIDER: S-EPMC2374704 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature