Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication.

ABSTRACT:

Background

Chromosomal rearrangements, such as translocations and inversions, are recurrent phenomena during evolution, and both of them are involved in reproductive isolation and speciation. To better understand the molecular basis of chromosome rearrangements and their part in karyotype evolution, we have investigated the history of human chromosome 17 by comparative fluorescence in situ hybridization (FISH) and sequence analysis.

Results

Human bacterial artificial chromosome/p1 artificial chromosome probes spanning the length of chromosome 17 were used in FISH experiments on great apes, Old World monkeys and New World monkeys to study the evolutionary history of this chromosome. We observed that the macaque marker order represents the ancestral organization. Human, chimpa

SUBMITTER: Cardone MF 

PROVIDER: S-EPMC2374708 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature