Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes.

ABSTRACT:

Background

Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes. In cardiomyocytes, endothelin-1 rapidly (within minutes) stimulates protein kinase signaling, including extracellular-signal regulated kinases 1/2 (ERK1/2; though not ERK5), with phenotypic/physiological changes developing from approximately 12 h. Hypertrophy is associated with changes in mRNA/protein expression, presumably consequent to protein kinase signaling, but the connections between early, transient signaling events and developed hypertrophy are unknown.

Results

Using microarrays, we defined the early transcriptional responses of neonatal rat cardiomyocytes to endothelin-1 over 4 h, differentiating betw

SUBMITTER: Cullingford TE 

PROVIDER: S-EPMC2374717 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature