Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based comparative genomic hybridization (aCGH) to obtain a whole genome copy number profile relevant for identifying deranged pathways and clinically applicable markers.

Methods

A 32 k aCGH platform was used for high resolution mapping of copy number changes in 30 stage I-IV ESCC. Potential interdependent alterations and deranged pathways were identified and copy number changes were correlated to stage, differentiation and survival.

Results

Copy number alterations af

SUBMITTER: Carneiro A 

PROVIDER: S-EPMC2374796 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature