Network motif analysis of a multi-mode genetic-interaction network.

ABSTRACT: Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in open-source software. Motifs extracted from multi-mode genetic-interaction networks form functional subnetworks, highlight genes dominating these subnetworks, and reveal genetic reflections of the underlying biochemical system.

SUBMITTER: Taylor RJ 

PROVIDER: S-EPMC2374991 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature