The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small noncoding RNAs that bind mRNA target transcripts and repress gene expression. They have been implicated in multiple diseases, such as cancer, but the mechanisms of this involvement are not well understood. Given the complexity and degree of interactions between miRNAs and target genes, understanding how miRNAs achieve their specificity is important to understanding miRNA function and identifying their role in disease.

Results

Here we report factors that influence miRNA regulation by considering the effects of both single and multiple miRNAs targeting human genes. In the case of single miRNA targeting, we developed a metric that integrates miRNA and mRNA expression data to calculate how changes in miRNA expression affect target mRNA exp

SUBMITTER: Hon LS 

PROVIDER: S-EPMC2374997 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature