Quantitative genomics of locomotor behavior in Drosophila melanogaster.

ABSTRACT:

Background

Locomotion is an integral component of most animal behaviors, and many human health problems are associated with locomotor deficits. Locomotor behavior is a complex trait, with population variation attributable to many interacting loci with small effects that are sensitive to environmental conditions. However, the genetic basis of this complex behavior is largely uncharacterized.

Results

We quantified locomotor behavior of Drosophila melanogaster in a large population of inbred lines derived from a single natural population, and derived replicated selection lines with different levels of locomotion. Estimates of broad-sense and narrow-sense heritabilities were 0.52 and 0.16, respectively, indicating substantial non-additive genetic variance for locomotor behavior.

SUBMITTER: Jordan KW 

PROVIDER: S-EPMC2375002 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature