Metabolic peculiarities of Aspergillus niger disclosed by comparative metabolic genomics.

ABSTRACT:

Background

Aspergillus niger is an important industrial microorganism for the production of both metabolites, such as citric acid, and proteins, such as fungal enzymes or heterologous proteins. Despite its extensive industrial applications, the genetic inventory of this fungus is only partially understood. The recently released genome sequence opens a new horizon for both scientific studies and biotechnological applications.

Results

Here, we present the first genome-scale metabolic network for A. niger and an in-depth genomic comparison of this species to seven other fungi to disclose its metabolic peculiarities. The raw genomic sequences of A. niger ATCC 9029 were first annotated. The reconstructed metabolic network is based on the annotation of two A. niger genomes, CBS 51

SUBMITTER: Sun J 

PROVIDER: S-EPMC2375020 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature