Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression.

ABSTRACT:

Background

Tobacco use remains the leading preventable cause of death in the US. The risk of dying from smoking-related diseases remains elevated for former smokers years after quitting. The identification of irreversible effects of tobacco smoke on airway gene expression may provide insights into the causes of this elevated risk.

Results

Using oligonucleotide microarrays, we measured gene expression in large airway epithelial cells obtained via bronchoscopy from never, current, and former smokers (n = 104). Linear models identified 175 genes differentially expressed between current and never smokers, and classified these as irreversible (n = 28), slowly reversible (n = 6), or rapidly reversible (n = 139) based on their expression in former smokers. A greater percentage of i

SUBMITTER: Beane J 

PROVIDER: S-EPMC2375039 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature