Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation.

ABSTRACT:

Background

Accumulating evidence suggests an important role for the enzyme poly(ADP-ribose) polymerase-1 (PARP-1) as an integral part of the gene expression regulatory machinery during development and in response to specific cellular signals. PARP-1 might modulate gene expression through its catalytic activity leading to poly(ADP-ribosyl)ation of nuclear proteins or by its physical association with relevant proteins. Recently, we have shown that PARP-1 is activated during T cell activation. However, the proposed role of PARP-1 in reprogramming T cell gene expression upon activation remains largely unexplored.

Results

In the present study we use oligonucleotide microarray analysis to gain more insight into the role played by PARP-1 during the gene expression reprogramming tha

SUBMITTER: Saenz L 

PROVIDER: S-EPMC2375913 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature