Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice.

ABSTRACT: Transcription factors regulate tissue patterning and cell fate determination during development; however, expression of early regulators frequently abates upon differentiation, suggesting that they may also play a role in maintaining an undifferentiated phenotype. The transcription factor paired box 3 (Pax3) is expressed by multipotent neural crest precursors and is implicated in neural crest disorders in humans such as Waardenburg syndrome. Pax3 is required for development of multiple neural crest lineages and for activation of lineage-specific programs, yet expression is generally extinguished once neural crest cells migrate from the dorsal neural tube and differentiate. Using a murine Cre-inducible system, we asked whether persistent Pax3 expression in neural crest derivatives would aff

SUBMITTER: Wu M 

PROVIDER: S-EPMC2381747 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature