Conserved co-expression for candidate disease gene prioritization.

ABSTRACT:

Background

Genes that are co-expressed tend to be involved in the same biological process. However, co-expression is not a very reliable predictor of functional links between genes. The evolutionary conservation of co-expression between species can be used to predict protein function more reliably than co-expression in a single species. Here we examine whether co-expression across multiple species is also a better prioritizer of disease genes than is co-expression between human genes alone.

Results

We use co-expression data from yeast (S. cerevisiae), nematode worm (C. elegans), fruit fly (D. melanogaster), mouse and human and find that the use of evolutionary conservation can indeed improve the predictive value of co-expression. The effect that genes causing the same diseas

SUBMITTER: Oti M 

PROVIDER: S-EPMC2383918 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature